Understanding cancer's niche

Understanding microbe-induced cancers.

Microbes are important causes of human cancers, and our estimation of their significance continues to grow as cancer biology is better dissected. A classification system is proposed that highlights common and proposed microbe-induced pathways toward oncogenesis, with an emphasis on types of targeted cells and host-microbial interactions. The central principles that underlie oncogenesis induced ...

Understanding the Origins of Morphological Diversity: the Linguistic Niche Hypothesis

Human language is unparalleled in both its expressive capacity and its diversity. What accounts for the enormous diversity of human languages [13]? Recent evidence suggests that the structure of languages may be shaped by the social and demographic environment in which the languages are learned and used. In an analysis of over 2,000 languages Lupyan and Dale [25] demonstrated that socio-demogra...

Molecular understanding of KRAS- and BRAF-mutated colorectal cancers

Current Understanding of the Role of PPARγ in Gastrointestinal Cancers

Numerous studies have indicated that PPARγ plays multiple roles such as in inflammation, cell cycle control, cell proliferation, apoptosis, and carcinogenesis, thus PPARγ contributes to the homeostasis. Many in vitro studies have showed that ligand-induced activation of PPARγ possess antitumor effect in many cancers including CRC. However, the role of PPARγ in gastrointestinal cancers, especial...

Current understanding of mdig/MINA in human cancers

UNLABELLED Mineral dust-induced gene, mdig has recently been identified and is known to be overexpressed in a majority of human cancers and holds predictive power in the poor prognosis of the disease. Mdig is an environmentally expressed gene that is involved in cell proliferation, neoplastic transformation and immune regulation. With the advancement in deciphering the prognostic role of mdig i...